Conjugates of N-hydroxypropymethacrylamide-methacrylate copolymer with nuclide activation agent and/or anti-cancer compounds
US7662360B2 · kind B2 · utility
3Cited by
3References
14Claims
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Key dates
| Filing date | Jul 4, 2003 |
| Grant date | Feb 16, 2010 |
| Priority date | — |
| Expiry date | Apr 26, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to new anti-cancer compounds and in particular to new compounds for use in nuclide activation therapy, such as neutron capture therapy. Specifically this invention provides a conjugate having the general formula P-(L-NAT)n wherein P represents an N-hydroxypropylmethacrylamide-methacrylate copolymer having a molecular weight of 5-6,000 kDa; NAT represents a nuclide activation therapy agent; L represents a linker moiety capable of linking the polymer to the neutron capture therapy agent; and n represents an integer from 1-1,000.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.