Eg5 co-crystals
US7662581B1 · kind B1 · utility
9Cited by
2References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 20, 2004 |
| Grant date | Feb 16, 2010 |
| Priority date | — |
| Expiry date | Dec 21, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B15/00
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
This invention provides methods of identifying an Eg5 binding ligand. The ligand is identified by using the atomic coordinates of an Eg5 crystal to generate a three dimensional structure. The three dimensional structure is used in molecular modeling techniques and docking experiments to identify ligands that bind to the binding pocket of Eg5. A novel binding pocket is identified. The invention also provides a crystallized Eg5 and ligand complex.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.