Patent · US Expired

Polynucleotide intercalator interceptors and inhibitors

US7662767B2 · kind B2 · utility

0Cited by
1References
11Claims
0Family size

Assignee

Inventor

Key dates

Filing dateDec 6, 2001
Grant dateFeb 16, 2010
Priority date—
Expiry dateMay 22, 2023

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61P35/00
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

A method of using modified xanthine molecules as a binding agent is disclosed. Xanthine molecules with at least one substitution of a methyl group at the N1, N3, N7, or N9 position bind to intercalating molecules efficiently. This method can be applied to inhibiting intercalating molecules from binding to nucleic acids, as well as removing intercalating molecules that have been bound to nucleic acids. This method can also be applied to synthesize an efficient drug delivery system for compounds that have low solubility in aqueous media, including anti-neoplastic agents. The method can also be applied to flurosecently labeling nucleic acids.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.