Halide-free glucosamine-acidic drug complexes
US7662802B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 31, 2007 |
| Grant date | Feb 16, 2010 |
| Priority date | — |
| Expiry date | Mar 9, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/50
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A complex of glucosamine having a purity of at least about 99 wt. % and a maximum halide content of about 0.01 wt. %, and a therapeutic drug having a pKa of less than 7. Preferably, the complex is stabilized by coating it with at least one pharmaceutically acceptable polymer comprising a water-soluble, water-immiscible and/or water-swellable homopolymer and/or copolymer. Suitable polymers include carboxypolymethylene homopolymers and copolymers; polyethylene glycol homopolymers and copolymers, povidone homopolymers and copolymers; polyacrylic acid homopolymers and copolymers; polyacrylamide homopolymers and copolymers; polysaccharides; and mixtures of two or more of the foregoing polymers. The resultant coated complex will be stable upon exposure to ambient temperature and/or the atmosphere. Suitable therapeutic drugs fall into the following classes: α- and β-Adrenergic Agonists; Narcotic and Non-Narcotic Analgesics; Anorexics; Antiallergics; Antianginals; Antiarrhythmics; Antiasthmatics; Antibiotics; Anticoagulants; Anticonvulsants; Antidepressants; Antidiabetics; Antihistaminics; Antihypertensives; Nonsteroidal Anti-Inflammatories; Antimigraines; Antineoplastics; Antiparkinsonian…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.