Tetracyclic indole derivatives as antiviral agents

US7662809B2 · kind B2 · utility

Assignee

• Istituto di Recerche di Biologia Molecolare P. Angeletti S.R.L. · IT

Inventors

• Caterina Ercolani · Roma, IT
• Joerg Habermann · Roma, IT
• Frank Narjes · Ariccia, IT
• Simona Ponzi · Pomezia, IT
• Michael Rowley · Roma, IT
• Ian Stansfield · Roma, IT

Key dates

• Filing date: Oct 25, 2005
• Grant date: Feb 16, 2010
• Expiry date: Oct 25, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to tetracyclic indole compounds of formula (I); wherein R1, R2, R14, R15, A, Ar, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.