Polyomavirus diagnostic reagents
US7662912B2 · kind B2 · utility
1Cited by
2References
10Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Nov 19, 2008 |
| Grant date | Feb 16, 2010 |
| Priority date | — |
| Expiry date | Nov 19, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/708
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to HLA-A*02-restricted cellular epitopes within the VP1 polypeptide of human polyomaviruses, which are useful as diagnostic reagents for virus infection. Preferred peptides correspond to amino acids residues 107-116, 108-116 and 44-52 of BKV VP1, and are processed in vivo in natural infection with BKV. Effector T cell populations stimulated by the peptides represent functional CTLs as assessed by cytotoxicity and cytokine production, and are reactive against cells presenting both the BKV peptides above and the JC virus homolog sequences.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.