Anti-FcRn antibodies for treatment of auto/allo immune conditions

US7662928B2 · kind B2 · utility

Assignee

• The Research Foundation of the State University of New York · US

Inventors

• Joseph P. BALTHASAR · Lancaster, US
• Ryan Hansen · Carmel, US
• Feng Jin · Foster City, US

Key dates

• Filing date: Dec 6, 2006
• Grant date: Feb 16, 2010
• Expiry date: Dec 6, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/76
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Antibodies to heavy chain of human FcRn are provided which function as non-competitive inhibitors of IgG binding to FcRn. The antibodies may be polyclonal, monoclonal, chimeric or humanized, or antigen binding fragments thereof. These antibodies are useful for reducing the concentration of pathogenic IgGs in individuals and therefore used as a therapeutic tool in autoimmune and alloimmune conditions.