Anti-infective agents

US7662958B2 · kind B2 · utility

Inventors

• Rolf Wagner · Antioch, US
• Pamela L. Donner · Mundelein, US
• Dale J. Kempf · Libertyville, US
• Clarence J. Maring · Libertyville, US
• Vincent S. Stoll · Libertyville, US
• Yi-Yin Ku · Buffalo Grove, US
• Yu Pu · Gurnee, US

Key dates

• Filing date: Jul 13, 2007
• Grant date: Feb 16, 2010
• Expiry date: Jul 13, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides HCV polymerase inhibiting compounds having the formula (I):where R1 is cyclobutyl-N(Ra)—, n is 1, 2, 3 or 4, and at least one R5 is RaSO2N(Rj)alkyl-. In a non-limiting example, a compound of the present invention is N-[(3-{1-[(cyclobutyl)amino])-4-hydroxy -2-oxo-1,2-dihydro-quinolin-3-yl}-1,1-dioxo-1,4-dihydro-1λ6-thieno[2,3-e][1,2,4]thiadiazin-7-yl)methyl]methane-sulfonamide. The present invention also features compositions comprising the compounds of the present invention or pharmaceutically acceptable salts, stereoisomers or tautomers thereof, and methods of using the same to treat or prevent HCV infection.