Beta-strand mimetics and method relating thereto
US7662960B2 · kind B2 · utility
4Cited by
4References
4Claims
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Assignee
Inventors
Key dates
| Filing date | May 30, 2003 |
| Grant date | Feb 16, 2010 |
| Priority date | — |
| Expiry date | Dec 7, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Conformationally constrained compounds of structure:which mimic the secondary structure of β-strand regions of biologically active peptides and proteins are disclosed. Such β-strand mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents that inhibit protease, kinase and the like. Libraries containing the β-strand mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.