Methods for synthesis of acyloxyalkyl compounds
US7662987B2 · kind B2 · utility
7Cited by
10References
51Claims
0Family size
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Key dates
| Filing date | Jul 15, 2004 |
| Grant date | Feb 16, 2010 |
| Priority date | — |
| Expiry date | Mar 7, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in high yield, do not require the use of activated intermediates and/or toxic compounds and are readily amenable to scale-up.
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