Multicomponent vaccines

US7666438B1 · kind B1 · utility

Assignees

• INHIBITEX, INC. · US
• The Provost Fellows and Scholars of the College of the Holy and Undivived Trinity of Queen Elizabeth Near Dublin · IE
• THE TEXAS A&M UNIVERSITY SYSTEM · US

Inventors

• Joseph M. Patti · Weslaco, US
• Timothy J. Foster · Dublin, IE
• Magnus Hook · Houston, US

Key dates

• Filing date: Mar 9, 2004
• Grant date: Feb 23, 2010
• Expiry date: Dec 31, 2024

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Multicomponent vaccines are provided which aid in the prevention and treatment of staphylococcal infections and which include certain selected combinations of bacterial binding proteins or fragments thereof, or antibodies to those proteins or fragments. By careful selection of the proteins, fragments, or antibodies, a vaccine is provided that imparts protection against a broad spectrum of Staphylococcus and other bacterial strains and against proteins that are expressed at different stages of the logarithmic growth curve. In one embodiment of the invention, a composition is provided that includes a fibrinogen binding domain of a fibrinogen binding protein and a bacterial component such as ca capsular polysaccharide, and both active and passive vaccines based on these components are also provided, along with methods of treating infection using these compositions and vaccines.