Method of screening test substances for treating or preventing a disease mediated by plasma cells
US7666587B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Apr 11, 2003 |
| Grant date | Feb 23, 2010 |
| Priority date | — |
| Expiry date | Aug 3, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a method of screening a compound for potential effectiveness in treating or preventing a mammalian disease mediated by plasma cells or a mammalian disease caused by virus infection of mammalian cells. Compounds are tested for their ability to inhibit IRE1-mediated processing of untranslatable XBP-1 mRNA into translatable XBP-1 mRNA. Drugs that are useful in treating or preventing a mammalian disease mediated by plasma cells and a method for detecting XBP-1 activity in living cells are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.