Modified soluble T cell receptor
US7666604B2 · kind B2 · utility
61Cited by
3References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 9, 2003 |
| Grant date | Feb 23, 2010 |
| Priority date | — |
| Expiry date | Oct 12, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/70539
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a soluble T cell receptor (sTCR), which comprises (i) all or part of a TCR $g(a) chain, except the transmembrane domain thereof, and (ii) all or part of a TCR $g(b) chain, except the transmembrane domain thereof. (i) and (ii) each comprise a functional variable domain and at least a part of the constant domain of the TCR chain, and are linked by a disulphide bond between constant domain residues which is not present in native TCR, characterized in that the sTCR recognizes a CD1-antigen complex, a bacterial superantigen or a peptide-MHC/superantigen complex.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.