Mutants of the P4 protein of nontypable Haemophilus influenzae with reduced enzymatic activity

US7666626B2 · kind B2 · utility

Assignees

• Wyeth, LLC · US
• The Curators of the University of Missouri · US

Inventors

• Bruce A. Green · Pittsford, US
• Gary W. Zlotnick · New Windsor, US
• Leah Diane Fletcher · Richmond, US
• Arnold L. Smith · Oskaloosa, US
• Thomas J. Reilly · Columbia, US

Key dates

• Filing date: Dec 17, 2008
• Grant date: Feb 23, 2010
• Expiry date: Dec 17, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K39/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typable H. influenzae (NTHi) is useful as an active component in an immunogenic composition for humans. Methods of using these proteins, and compositions containing them in combination with additional antigens, are also provided.