Antiviral nucleosides

US7666856B2 · kind B2 · utility

Assignee

• MEDIVIR AB · SE

Inventors

• Nils-Gunnar Johansson · Huddinge, SE
• Genadiy Kalyanov · Huddinge, SE
• Joseph Armstrong Martin · Harpenden, GB
• David Bernard Smith · San Mateo, US
• Anna Winqvist · Huddinge, SE

Key dates

• Filing date: Oct 10, 2007
• Grant date: Feb 23, 2010
• Expiry date: Oct 10, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

4-Amino-1-((2R,3S,4S,5R)-5-azido-4-hydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (22) and prodrugs thereof are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process.