Antithrombotic diamides

US7666866B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Jeffry Bernard Franciskovich · Zionsville, US
• David Kent Herron · Indianapolis, US
• Valentine Joseph Klimkowski · Carmel, US
• Angela Lynn Marquart · Greenwood, US
• John Joseph Masters · Fishers, US
• David Mendel · Indianapolis, US
• Andrew Michael Ratz · Greenwood, US
• Gerald Floyd Smith · Indianapolis, US
• Michael Robert Wiley · Zionsville, US
• Ying Kwong Yee · Kennett Square, US

Key dates

• Filing date: Nov 15, 2005
• Grant date: Feb 23, 2010
• Expiry date: Aug 31, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.