Substituted azole aromatic heterocycles as inhibitors of 11β-HSD-1

US7666888B2 · kind B2 · utility

Assignees

• AMGEN INC. · US
• Biovitrum AB · SE

Inventors

• Michael D. Bartberger · West Hollywood, US
• Christopher H. Fotsch · Thousand Oaks, US
• Martin Haraldsson · Täby, SE
• David J. St. Jean, Jr. · Camarillo, US
• Lars Johansson · Bromma, SE
• Marianne Nilsson · Rimbo, SE
• Lori Sutin · Knivsta, SE
• Katrina Flyrén · Solna, SE

Key dates

• Filing date: Jul 18, 2007
• Grant date: Feb 23, 2010
• Expiry date: Jul 18, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula I and IV are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorder:wherein the variables A-B, R1, R2, m, and Q are described herein.