Patent · US Active

Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function

US7666983B2 · kind B2 · utility

23Cited by

3References

4Claims

0Family size

Assignees

BAYER HEALTHCARE LLC · DE
The Wistar Institute · US

Inventors

Thanos Halazonetis · Philadelphia, US
Wolfgang Hartwig · Wuppertal, DE

Key dates

Filing date	Mar 9, 2007
Grant date	Feb 23, 2010
Priority date	—
Expiry date	Sep 6, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K14/82
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360-386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53 and of select tumor-derived p53 mutants. Pharmaceutical compositions of the compounds of the invention and methods of using these compositions therapeutically are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.