Patent · US Active

αvβ3-specific antibodies

US7667007B2 · kind B2 · utility

0Cited by

16References

5Claims

0Family size

Assignee

Applied Molecular Evolution, Inc. · US

Inventors

William D. Huse · Del Mar, US
Herren Wu · Boyds, US

Key dates

Filing date	Apr 14, 2008
Grant date	Feb 23, 2010
Priority date	—
Expiry date	Apr 14, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/565
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention provides enhanced LM609 grafted antibodies exhibiting selective binding affinity to αvβ3, or a functional fragment thereof. The invention also provides nucleic acid molecules encoding the enhanced LM609 grafted antibodies. Additionally provided are methods of inhibiting a function of αvβ3 by contacting αvβ3 with an enhanced LM609 grafted antibody.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.