Amide forming chemical ligation
US7667076B2 · kind B2 · utility
2Cited by
1References
28Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 14, 2005 |
| Grant date | Feb 23, 2010 |
| Priority date | — |
| Expiry date | Nov 26, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0815
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An amide is formed by reacting an α-ketoacid or salt thereof in a decarboxylative condensation reaction with an amine or salt thereof comprising a nitrogen covalently bound to an atom selected from oxygen, nitrogen, and sulfur. The amide bond is formed between the α-carbon of the ketoacid and the nitrogen of the amine. The α-ketoacid can be formed using a novel sulfur reagent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.