HCV NS-3 serine protease inhibitors

US7671032B2 · kind B2 · utility

Assignee

• MEDIVIR AB · SE

Inventors

• Asa Annica Kristina Rosenquist · Huddinge, SE
• Fredrik Thorstensson · Linköping, SE
• Per-Ola Mikael Johansson · Linköping, SE
• Ingemar Kvarnstrom · Linköping, SE
• Bertil Samuelsson · Huddinge, SE
• Hans Wallberg · Stuvsta-Snättringe, SE

Key dates

• Filing date: Jan 28, 2005
• Grant date: Mar 2, 2010
• Expiry date: May 19, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Peptidomimetic compounds are described which inhibit the NS3 protease of the hepatitis C virus (HCV). The compounds have the formula where the variable definitions are as provided in the specification. The compounds comprise a carbocyclic P2 unit in conjunction with a novel linkage to those portions of the inhibitor more distal to the nominal cleavage site of the native substrate, which linkage reverses the orientation of peptidic bonds on the distal side relative to those proximal to the cleavage site.