Positively-charged peptide nucleic acid analogs with improved properties

US7671036B2 · kind B2 · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Jehoshua Katzhendler · Jerusalem, IL
• Ada Schlossman · Jerusalem, IL
• Yousuf Najajreh · Shfaram, IL
• Dan Gibson · Jerusalem, IL

Key dates

• Filing date: Jun 22, 2001
• Grant date: Mar 2, 2010
• Expiry date: Jan 22, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel types of peptide nucleic acids (PNAS) with improved properties. In particular, it relates to positively charged PNA units having an ethylene linker between the backbone and the nucleobase, to oligonucleotide analogs comprising these units, to oligomers comprising these units, and to the use of positively charged PNAs as novel delivery agents with therapeutic and diagnostic applications including for antisense therapy.