Closed loop flow control of a HPLC constant flow pump to enable low-flow operation
US7674375B2 · kind B2 · utility
6Cited by
9References
8Claims
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Key dates
| Filing date | May 20, 2005 |
| Grant date | Mar 9, 2010 |
| Priority date | — |
| Expiry date | May 20, 2025 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/324
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method and apparatus for monitoring and controlling nano-scale flow rate of fluid in the operating flow path of a HPLC system provide fluid flow without relying on complex calibration routines to compensate for solvent compositions gradients typically used in HPLC. The apparatus and method are used to correct the flow output of a typical, analytical-scale (0.1-5 mL/min) HPLC pump to enable accurate anti precise flow delivery at capillary (<0.1 mL/min) and nano-scale (<μL/min) HPLC flow rates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.