Transfected cell line and a method using the same for the high throughput screening for inhibitors of the T-type calcium channel alpha-1H
US7674596B2 · kind B2 · utility
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3References
7Claims
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Key dates
| Filing date | Sep 12, 2005 |
| Grant date | Mar 9, 2010 |
| Priority date | — |
| Expiry date | Dec 28, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/705
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to a cell line in which a potassium channel is introduced. More specifically, it is a cell line capable of activating the T-type α1H calcium channel by depolarization wherein a vector encoding a potassium channel is introduced. Since the cell line of the present invention is available for a high throughput screening of candidate T-type α1H calcium channel inhibitors, it may accelerate the development of therapeutic agents for diseases related to T-type α1H calcium channels.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.