Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole

US7674813B2 · kind B2 · utility

Assignee

• Wyeth, LLC · US

Inventors

• Lynn Resnick · Sayreville, US
• Donna M. Huryn · Allentown, US
• Joan E. Sabalski · Yardville, US
• Joshua D. Berkowitz · Carbondale, US
• Anthony Kreft · Langhorne, US
• Dennis M. Kubrak · Philadelphia, US
• Thomas Joseph Caggiano · Levittown, US
• Koi Michele Morris · Plainsboro, US

Key dates

• Filing date: Jun 19, 2008
• Grant date: Mar 9, 2010
• Expiry date: Jun 19, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds useful for lowering beta amyloid levels are provided. The compounds have the structure of formula Ia:wherein, R1 is lower alkyl, substituted lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, benzyloxy, substituted benzyloxy, or SO2R5; R5 is phenyl, substituted phenyl, heterocycle, substituted heterocycle, alkyl, or substituted alkyl; R2 is lower alkyl, substituted lower alkyl, CF3, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, or cycloalkyl; R3 is hydrogen, lower alkyl, or substituted lower alkyl; R4 is phenyl, substituted phenyl, heterocycle, substituted heterocycle, thiophene, or substituted thiophene; R6 is hydrogen, lower alkyl, substituted lower alkyl, CF3, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, cycloalkyl, or substituted cycloalkyl; W, X and Y are independently CR7 or N; and R7 is hydrogen, halogen, lower alkyl, or substituted lower alkyl.