Arrays of biological membranes and methods and use thereof

US7678539B2 · kind B2 · utility

Assignee

• CORNING INCORPORATED · US

Inventors

• Ye Fang · Corning, US
• Anthony G. Frutos · Corning, US
• Steven J. Jonas · Bloomfield Hills, US
• Peter Kalal · Corning, US
• Joydeep Lahiri · Corning, US

Key dates

• Filing date: Oct 9, 2001
• Grant date: Mar 16, 2010
• Expiry date: Apr 18, 2023

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/02
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention overcomes the problems and disadvantages associated with prior art arrays by providing an array comprising a plurality of biological membrane microspots associated with a surface of a substrate that can be produced, used and stored, not in an aqueous environment, but in an environment exposed to air under ambient or controlled humidities. Preferably, the biological membrane microspots comprise a membrane bound protein. Most preferably, the membrane bound protein is a G-protein coupled receptor, an ion channel, a receptor serine/threonine kinase or a receptor tyrosine kinase.