Intermediates for imidazonaphthyridines

US7678918B2 · kind B2 · utility

Assignees

• 3M INNOVATIVE PROPERTIES COMPANY · US
• Graceway Pharmaceuticals. LLC · US

Inventors

• John F. Gerster · Woodbury, US
• Kyle J. Lindstrom · Houlton, US
• Stephen L. Crooks · Mahtomedi, US
• Philip D. Heppner · Woodbury, US
• Gregory J. Marszalek · Windom, US
• Peter Maye · Windom, US
• Bryon A. Merrill · River Falls, US
• John Mickelson · Mattawan, US
• Michael J. Rice · Oakdale, US

Key dates

• Filing date: Dec 6, 2007
• Grant date: Mar 16, 2010
• Expiry date: Dec 6, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.