Method for producing pentacyclic taxans
US7678919B2 · kind B2 · utility
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Key dates
| Filing date | Sep 25, 2008 |
| Grant date | Mar 16, 2010 |
| Priority date | — |
| Expiry date | Sep 25, 2028 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Taxan derivatives are produced efficiently and inexpensively, which are useful as oral-administrable antitumor compounds.A compound of formula (1) (wherein R1 is an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group; R2 is a hydroxyl group optionally having a protective group) is processed with an alkali metal permanganate to produce a compound of formula (2), which may be a starting material for oral-administrable antitumor compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.