Method for the enantiomoeric separation of optical active amlodipine
US7678921B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Dec 3, 2004 |
| Grant date | Mar 16, 2010 |
| Priority date | — |
| Expiry date | May 19, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to the preparation of the (S)-(−)-amlodipine and (R)-(+)-amlodipine by means of enantiomeric separation of racemic amlodipine mixture, in which, L- or D-tartaric acid is used as resolution agent, and organic solvent containing 2-butanone is used as solvent. The 2-butanone used in the present invention has the advantage of low boiling point, low toxicity, litter pollution, and the method is suitable for large-scaled production.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.