Process for lactonization in the preparation of statins
US7678927B2 · kind B2 · utility
0Cited by
11References
12Claims
0Family size
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Key dates
| Filing date | Sep 8, 2004 |
| Grant date | Mar 16, 2010 |
| Priority date | — |
| Expiry date | Sep 8, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D309/30
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to an improved and industrial friendly process for lactonization to produce compound of the Formula [I], from compound of the Formula [II] in presence of an inorganic compound as a suitable lactonizing agent, preferably alkali metal hydrogen sulfate, and crystallizing the obtained lactone product in a solvent; or treating compound of the Formula [II] in the presence of an inorganic compound preferably alkali metal hydrogen sulfate using phase transfer catalyst in heterogeneous phase followed by crystallizing the obtained lactone product in a solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.