Assay apparatus and method using microfluidic arrays

US7682565B2 · kind B2 · utility

Assignee

• BioTrove, Inc. · US

Inventors

• John Linton · Lincoln, US
• Karl Yoder · Stoneham, US
• Robert Hess · Cambridge, US
• Leila Hasan · Boston, US
• Robert Ellis · Bellingham, US
• Tanya S. Kanigan · Cambridge, US
• Kristine Friesen · Cambridge, US
• Arrin Katz · Cambridge, US
• Colin Brenan · Marblehead, US
• Tom Morrison · Winchester, US
• Javier Garcia · València, ES

Key dates

• Filing date: Dec 22, 2003
• Grant date: Mar 23, 2010
• Expiry date: Apr 29, 2028

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/2575
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.