Patent · US Active

Polymorphis of a known thiophenecarboxylic acid dodecahydrocyclopenta (a) phenanthrenyl ester

US7683048B2 · kind B2 · utility

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10Claims

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Assignee

Novartis AG · CH

Inventors

Guido Jordine · Glückstadt, DE
Michael Mutz · Glückstadt, DE

Key dates

Filing date	Jul 28, 2003
Grant date	Mar 23, 2010
Priority date	—
Expiry date	Jan 23, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07J33/002
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Polymorphic crystal forms of 3-methylthiophene-2-carboxylic acid (6S,9R,10S,11S,13S,16R, 17R)-9-chloro-6-fluoro-11-hydroxy-17-methoxycarbonyl-10,13,16-trimethyl-3-oxo-6,7,8,9,10, 11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester. The crystal forms possess anti-inflammatory activity and have very good stability. Methods for preparing the crystal forms are also described.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.