Process for the preparation of Rivastigmine

US7683205B2 · kind B2 · utility

Assignee

• Alembic Ltd. · IN

Inventors

• Pandurang Balwant Deshpande · Vadodara, IN
• Kishore Khemani · Vadodara, IN
• Bharat Becharbhai Boda · Vadodara, IN
• Tushar Rajnikant Shah · Vadodara, IN
• Hitarth Harshendu Acharya · Vadodara, IN
• Parven Kumar Luthra · Vadodara, IN

Key dates

• Filing date: Oct 31, 2006
• Grant date: Mar 23, 2010
• Expiry date: May 19, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C269/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to an improved process for preparation of Rivastigmine of formula (I) or pharmaceutically acceptable salts thereof comprising a step of N-methylation of compound of formula (III), wherein R1=R2=H or R1=H and R2=CH3 or an acid addition salt thereof, using paraformaldehyde in the presence of Raney Nickel and hydrogen in a suitable solvent to obtain compound of formula (II).