Sinus delivery of sustained release therapeutics

US7686798B2 · kind B2 · utility

Assignee

• Sinexus, Inc. · US

Inventors

• Donald J. Eaton · Los Altos, US
• Mary L. Moran · Woodside, US
• Rodney Brenneman · Dana Point, US

Key dates

• Filing date: Apr 7, 2009
• Grant date: Mar 30, 2010
• Expiry date: Apr 7, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P11/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.