Substituted spirobenzazepines

US7687494B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Mona Patel · Montgomery, US
• Philip Rybczynski · Somerville, US
• Min Xiang · Bound Brook, US

Key dates

• Filing date: Apr 13, 2007
• Grant date: Mar 30, 2010
• Expiry date: Apr 13, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D223/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is directed to nonpeptide substituted benzazepines of Formula I, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency, including congestive heart failure, hyponatremia, and hypertension, among others disclosed. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, hyponatremia, renal vasospasm, renal failure, diabetic nephropathy, cerebral edema, cerebral ischemia, stroke, thrombosis, or water retention are also disclosed.