Patent · US Active

Method of manufacturing labelled oligonucleotide conjugates

US7687618B2 · kind B2 · utility

0Cited by

3References

9Claims

0Family size

Assignee

NimbleGen Systems GmbH · US

Inventors

Klaus-Peter Stengele · Pleiskirchen, DE
Evgueni Kvassiouk · Waldkraiburg, DE

Key dates

Filing date	Oct 14, 2003
Grant date	Mar 30, 2010
Priority date	—
Expiry date	Nov 20, 2026

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to a method for the manufacture of labeled oligonucleotide conjugates comprising the reaction of (a) an oligonucleotide having a labile protecting group bound to a terminal hydroxy group, and (b) a labeling compound, wherein said labile protecting group is partially or completely substituted by said labeling compound in a nucleophilic substitution reaction.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.