Microfluidic device for controlling sample introduction in microcolumn separation techniques and sampling device
US7691245B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Dec 21, 2005 |
| Grant date | Apr 6, 2010 |
| Priority date | — |
| Expiry date | Sep 3, 2028 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N27/44791
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A microfluidic device for controlling sample introduction in microcolumn separation techniques, more particularly in capillary electrophoresis (CE), where a sample is injected as a sample plug into a sampling device which comprises at least a channel for the electrolyte buffer and a supply and drain channel for the sample. The supply and drain channels discharge into the electrolyte channel at respective supply and drain ports. The distance between the supply port and the drain port geometrically defines a sample volume. The injection of the sample plug into the electrolyte channel is accomplished electrokinetically by applying an electric field across the supply and drain channels for a time at least long enough that the sample component having the lowest electrophoretic mobility is contained within the geometrically defined volume. Means are provided for electrokinetically injecting the sample into the sample volume.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.