Gene inactivated mutants with altered protein production
US7691621B2 · kind B2 · utility
11Cited by
12References
17Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Apr 11, 2006 |
| Grant date | Apr 6, 2010 |
| Priority date | — |
| Expiry date | Nov 4, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y110/03002
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A recombinant filamentous fungal cell (e.g. Aspergillus) having one or more inactivated chromosomal genes is provided. The chromosomal genes in some embodiments correspond to derA, derB, htmA, mnn9, mnn10, ochA, dpp4, dpp5, pepAa, pepAb, pepAc, pepAd, pepF and combinations thereof. The recombinant fungal cells may include further inactivated chromosomal genes which correspond to pepA, pepB, pepC and pepD. The recombinant filamentous fungal cells may include a heterologous nucleic acid encoding a protein of interest. Also provided are methods of producing a protein of interest in said recombinant filamentous fungal cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.