Dihydropyridine derivatives for use as human neutrophil elastase inhibitors

US7691854B2 · kind B2 · utility

Assignee

• Bayer Schering Pharma AG · DE

Inventors

• Heike Gielen-Haertwig · Monheim, DE
• Volkhart Min-Jian Li · Velbert, DE
• Ulrich Rosentreter · Binnen, DE
• Karl-Heinz Schlemmer · Wuppertal, DE
• Swen Allerheiligen · Wuppertal, DE
• Leila Telan · Wuppertal, DE
• Lars Bärfacker · Oberhausen, DE
• Jörg Keldenich · Wuppertal, DE
• Mary F. Fitzgerald · Yarnton, GB
• Kevin Nash · Seffner, US
• Barbara Albrecht · Wuppertal, DE
• Dirk Meurer · Wunstorf, DE

Key dates

• Filing date: Aug 18, 2003
• Grant date: Apr 6, 2010
• Expiry date: Jul 12, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel dihydropyridine derivatives, of Formula (I) processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.