Three component chimeric antisense oligonucleotides
US7691996B2 · kind B2 · utility
0Cited by
13References
21Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Jan 14, 2005 |
| Grant date | Apr 6, 2010 |
| Priority date | — |
| Expiry date | Jan 14, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/346
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention relates to antisense oligonucleotides that target mRNAs in cells as substrates for the cellular enzyme RNase H and thereby cause specific degradation of the targeted mRNA. The oligonucleotides have three components: an RNase H activating region, a complementary region and 3′ and 5′ ends. The invention optimizes each of the components to resist intracellular nucleases, to increase hybridization to target mRNA, to specifically inactivate target mRNA in cells, and to decrease cytotoxicity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.