Metal complexes having vitamin B12 as a ligand
US7692002B2 · kind B2 · utility
13Cited by
7References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 10, 2005 |
| Grant date | Apr 6, 2010 |
| Priority date | — |
| Expiry date | Aug 9, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a metal complex of the general formula M(L)n, wherein each L is independently selected and represents a ligand and at least one L is vitamin B12 (cyanocobalamin) or a derivative thereof bound through the nitrogen atom of its cyanide group to M, which is an element selected from the transition metals, thus, forming a M-NC-[Co] moiety with [Co] representing vitamin B12 without cyanide and wherein n is 1, 2, 3, 4, 5 or 6. The complex can be prepared by mixing a precursor molecule with vitamin B12. The metal complexes can be used for radiodiagnostics, chemotherapy and radionuclide therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.