Patent · US Active

Process for the preparation of pyridylcarboxylic amides and esters

US7692020B2 · kind B2 · utility

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1References

16Claims

0Family size

Assignee

BASF SE

Inventors

Monika Brink · Ingelheim am Rhein, DE
Marcus Knell · Ingelheim am Rhein, DE
Jan Hendrik Wevers · Zörbig, DE

Key dates

Filing date	Oct 26, 2006
Grant date	Apr 6, 2010
Priority date	—
Expiry date	Oct 26, 2026

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D213/81
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to a process for the preparation of pyridylcarboxylic amides and esters I, Formula (I) wherein Hal, X and R1 have the meanings given in claim 1, which comprises the following steps: (a) heating a mixture consisting essentially of trichloromethylpyridine II, Formula (II), wherein Hal has the meaning given, and 1.0 to 1.5 equivalents of concentrated sulfuric acid, characterized in that the trichloromethylpyridine II in a liquid form is added to the concentrated sulfuric acid at a temperature from 110° C. to 160° C.; and (b) reacting the intermediate product obtained in step (a) with an amine or alcohol III, HXR1, wherein X and R1 have the meaning given, optionally in the presence of a solvent and/or a base.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.