Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives

US7692034B2 · kind B2 · utility

Assignee

• TEVA PHARMACEUTICAL INDUSTRIES, LTD. · IL

Inventors

• Reinhold Öhrlein · Rheinfelden (Baden), DE
• Gabriele Baisch · Binzen, DE
• Hans Jürg Kirner · Basel, CH
• Frank Bienewald · Versailles, FR
• Stephan Burkhardt · Gelterkinden, CH
• Martin Studer · Basel, CH

Key dates

• Filing date: Jan 24, 2007
• Grant date: Apr 6, 2010
• Expiry date: Jan 24, 2027

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XIX wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group, and Rb is a carboxy-protective group.