Method for manufacturing hydrogel biochip by using star-like polyethylene glycol derivative having epoxy group
US7695910B2 · kind B2 · utility
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13Claims
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Key dates
| Filing date | Aug 28, 2006 |
| Grant date | Apr 13, 2010 |
| Priority date | — |
| Expiry date | Jun 6, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B40/10
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for manufacturing a biochip and a biochip manufactured by the method are provided. In the biochip manufacturing method, a star-like polyethylene glycol derivative having an epoxy group at its terminal is reacted with a low molecular weight hydrophilic polymer to form a matrix, and a probe is covalently bound to the matrix and immobilized on a solid substrate. The biochip has a 3-dimensional structure where it spatially protrudes from its surface and improved chip sensitivity. In addition, the biochip can be conveniently and efficiently manufactured using an aqueous solution at low costs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.