Method for preparing 1,3-propanediol by a recombinant micro-organism in the absence of coenzyme B12 or one of its precursors
US7695943B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Aug 15, 2007 |
| Grant date | Apr 13, 2010 |
| Priority date | — |
| Expiry date | Nov 1, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P7/18
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention concerns a method for preparing 1,3-propanediol from a carbon-containing substance, said method comprising a step which consists in culturing a recombinant micro-organism not producing coenzyme B12 in the absence of coenzyme B12 or one of its precursors. The invention also concerns a nucleic acid coding for a glycerol dehydratase whereof the catalytic activity is independent of the presence of coenzyme B12 or one of its precursors and a nucleic acid coding for a 1,3-propanol dehydrogenase intervening in the synthesis of 1,3-propanediol. The invention further concerns recombinant vectors and host cells comprising said nucleic acids and the polypeptides coded by the latter.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.