Glutamic acid decarboxylase (GAD) based delivery systems
US7695959B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Mar 16, 2004 |
| Grant date | Apr 13, 2010 |
| Priority date | — |
| Expiry date | Feb 24, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding glutamic acid decarboxylase (GAD) to cells in the hippocampus, subthalamic nucleus of the basal ganglia, mesaphilia and thalamus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.