Compositions and methods for generating short double-stranded RNA using mutated RNAse III
US7695964B2 · kind B2 · utility
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Key dates
| Filing date | Jan 21, 2005 |
| Grant date | Apr 13, 2010 |
| Priority date | — |
| Expiry date | Oct 19, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2330/30
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Compositions and methods are provided for preparing an hsiRNA mixture and for silencing of gene expression in vivo. The composition relates to a mutant RnaseIII. The methods are directed to reacting a preparation of dsRNA with an effective amount of a mutant RNAse III to produce the hsiRNA mixture.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.