Phosphodiesterase 4 inhibitors

US7696198B2 · kind B2 · utility

Assignee

• Memory Pharmaceuticals Corporation · US

Inventors

• Ashok Tehim · Ridgewood, US
• Allen Hopper · Glen Rock, US
• Ruiping Liu · Beijing, CN
• Erik Kuester · Rochester, US
• Robert F. Dunn · Towaco, US
• Thomas Renau · Santa Clara, US

Key dates

• Filing date: Apr 16, 2004
• Grant date: Apr 13, 2010
• Expiry date: Oct 13, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula I:wherein R1, R2, and R3 are as defined herein.