CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions

US7696209B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Stephan Georg Mueller · Warthausen, DE
• Klaus Rudolf · Warthausen, DE
• Philipp Lustenberger · Warthausen, DE
• Dirk Stenkamp · Biberach, DE
• Marco Santagostino · Magenta, IT
• Fabio Paleari · Monza, IT
• Henri Doods · Warthausen, DE
• Kirsten Arndt · Biberach, DE
• Gerhard Schaenzle · Biberach, DE

Key dates

• Filing date: Jan 30, 2009
• Grant date: Apr 13, 2010
• Expiry date: Jan 30, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the CGRP-antagonists of general formula Iwherein R1, R2, R3, R4 and X are defined as in claim 1, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates, mixtures and salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, as well as those compounds of general formula I in which one or more hydrogen atoms are replaced by deuterium, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.