Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof
US7696244B2 · kind B2 · utility
2Cited by
2References
28Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 14, 2004 |
| Grant date | Apr 13, 2010 |
| Priority date | — |
| Expiry date | Jun 19, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P11/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides compositions, including pharmaceutical preparations, which comprise one or more substituted thiophene, benzofuran, pyrimidinetrione, dihydropyridine, tetrahydrocarbazol or anthraquinone compounds. The invention also features methods of use of such compositions in increasing activity of mutant-cystic fibrosis transmembrane conductance regulator protein in a cell, e.g. by increasing ion transport in a mutant-CFTR.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.